Sexual Maturation in a Eusocial Mammal

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RFamide-related peptide-3 (RFRP-3) suppresses sexualmaturation in a eusocial mammal

Question 1: Why are the researchers using naked mole rats as a study species for puberty? What advantages does the species provide?

Question 2: How does RFRP-3 act in the brain? What is the downstream effect on the HPG axis in adult mammals?

Question 3: What is a “reproductively quiescent adult” naked mole rat?

Question 4: What is an RFRP-immunoreactive (RFRP-ir) cell body? What does this tell the researchers?

Question 5: In one sentence, what was the goal of study 1?

Question 6: In one sentence, what was the goal of study 2?

Question 7: Study 3 was an experimental manipulation, supplying exogenous RFRP-3 to naked mole rats. What is intracerebroventricular (ICV) administration, and how did the researchers supply the treatment? What was the control?

Question 8: Look at figure 3. What effects did the treatment have compared to the control?