Pharmacokinetic Process in the Liver

Weekly discussion boards are comprised of multi-option topics and diverse learner content response options. Be sure to respond to two peers who have posted on options that are different from the one you have chosen.
WRITING TIP: To earn maximum points — use case examples, supportive documentation, or salient information from the textbook and/or external credible source. Be sure to cite and reference all sources in all three posts, giving credit to the authors while showing critical thinking beyond opinion. There are several websites “out there” that you may find helpful, but remember that websites are not credible sources. While you can certainly use websites to further bolster claims, websites should not be the only type of source listed.

Discussion Board Question [Option 2]
The liver is an essential organ in the pharmacokinetic process of many drugs. When selecting a drug and dosage regimen for a patient with liver disease, prescribers take additional considerations for altered pharmacodynamics and impaired renal excretion (hepatorenal syndrome). While much is still unknown, clinical studies suggest that there is a decrease in clearance of drugs or active metabolites normally cleared by the kidneys. As clinicians, we occasionally (or often, depending on what occupational environment) work with clients with liver disease secondary to alcohol abuse/dependency or clients with other types of liver disease, such as Hepatitis C. What are some indicators of hepatotoxicity in clients that clinicians should be aware of? Which medications are most likely to induce hepatotoxicity? See the attached required readings for this option located in the Resources tab. Indicate which option you are choosing at the start of the post.

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