Pharmacokinetics and Pharmacodynamic Aspects of Pharmacology

Directions (for all cases): For each of the scenarios below, answer the questionsbelow using clinical practice guidelines where applicable. Explain the problem andexplain how you would address the problem. If prescribing a new drug, write out acomplete medication order just as you would if you were completing a prescription. Useat least 3 sources for each scenario and cite sources using APA format. Each scenario should be about 250 words, excluding the references.Week 1 Cases1. A 52-year-old man was recently discharged from the hospital following treatmentfor atrial fibrillation. He was discharged on Warfarin 5 mg po q day andAmiodarone 200 mg tid. His INR is 8.8. What interaction has occurred with these2 medications? What changes in his medications would you make?2. A 44-year-old woman is currently taking Glipizide and Phenytoin. She has a newprescription for Ceftriaxone. All three medications are known to be highly proteinbound. What effect does protein binding have on drug availability? How wouldyou manage this patient’s medication?3. Name two drugs that are highly affected by the first pass effect. As a prescriber,what actions would you take in prescribing these drugs to counter the first passeffect?4. James is a 49-year-old male that was prescribed atenolol for his high bloodpressure. James states that he only occasionally takes the medication becausehe does not like the side effects. What information would you provide to thepatient at his visit? How would you manage his medication?