Cell Behavior

An understanding of cells and cell behavior is a critically important component of disease diagnosis and treatment. But some diseases can be complex in nature, with a variety of factors and circumstances impacting their emergence and severity.
Effective disease analysis often requires an understanding that goes beyond isolated cell behavior. Genes, the environments in which cell processes operate, the impact of patient characteristics, and racial and ethnic variables all can have an important impact.
An understanding of the signals and symptoms of alterations in cellular processes is a critical step in the diagnosis and treatment of many diseases. For APRNs, this understanding can also help educate patients and guide them through their treatment plans.
In this Assignment, you examine a case study and analyze the symptoms presented. You identify cell, gene, and/or process elements that may be factors in the diagnosis, and you explain the implications to patient health.

To prepare:
By Day 1 of this week, you will be assigned to a specific case study for this Case Study Assignment. Please see the “Announcements” section of the classroom for your assignment from your Instructor.
The Assignment
Develop a 1- to 2-page case study analysis in which you:
• Explain why you think the patient presented the symptoms described.
• Identify the genes that may be associated with the development of the disease.
• Explain the process of immunosuppression and the effect it has on body systems.
The CASE STUDY

The Week 2 Assignment 2 1 case study analysis assignment is based on the following scenario:
A 42-year-old female presents to the clinic with chief complaint of increased fatigue and joint pain worsening over the last few weeks. Her past medical history includes similar episodes with a prior ESR of 56 mm/hr and a negative ANA. She reports that she has had some episodes of chills but hasn’t taken her temperature. The patient reports that she takes ibuprofen for the pain which partially relieves her symptoms. The pain is sometimes worse in the morning but also occurs throughout the day. Her blood pressure is 124/78, heart rate 74, temperature 100 F.

Preferred Sources
Agency for Healthcare Research and Quality
Centers for Disease Control and Prevention
National Guideline Clearinghouse
U.S. Preventive Task Force
National Institutes of Health
LEARNING RESOURCES
Review the following Video Resources and Content Pages in the Lecturio Platform by clicking button below labeled Load Week 2: Learning Resources in a new window.
• Cell Injury and Adaptation: Introduction (3:09 min)
• Ischemia-reperfusion Injury (2:52 min)
• Atrophy and Autophagy (11:42 min)
• Hypertrophy (2:43 min)
Note: These readings are intended to serve as supplementary to the Lecturio content provided in this course. Please refer/review these supplementary resources should you need help in reinforcing concepts and in preparation for completing this week’s Assessments.
• McCance, K. L. & Huether, S. E. (2019). Pathophysiology: The biologic basis for disease in adults and children (8th ed.). St. Louis, MO: Mosby/Elsevier.
o Chapter 7: Innate Immunity: Inflammation and Wound Healing
o Chapter 8: Adaptive Immunity (stop at Generation of clonal diversity); Summary Review
o Chapter 9: Alterations in Immunity and Inflammation (stop at Deficiencies in immunity); Summary Review
o Chapter 10: Infection (stop at Infectious parasites and protozoans); (start at HIV); Summary Review
o Chapter 11: Stress and Disease (stop at Stress, illness & coping); Summary Review
o Chapter 12: Cancer Biology (stop at Resistance to destruction); Summary Review
o Chapter 13: Cancer Epidemiology (stop at Environmental-Lifestyle factors); Summary Review
• Justiz-Vaillant, A. A., & Zito, P. M. (2019). . In StatPearls. Treasure Island, FL: StatPearls Publishing. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK513315/
Credit Line: Immediate Hypersensitivity Reactions – StatPearls – NCBI Bookshelf. (2019, June 18). Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK513315/. Used with permission of Stat Pearls.