Case Study
- What does the acronym “APECED” stand for?
- Translate the terms in answer #1.
- What type of disease is APECED?
- Briefly, what is “negative selection” of T lymphocytes? Which cells are negatively selected?
- In the thymus, what is the specific fate of a lymphocyte that binds to self-antigens?
- What is “AIRE”?
- What is the pattern of inheritance for APECED?
- What human populations have the highest incidence of APECED?
- Name three autoimmune diseases that Robert was diagnosed with (other than the APECED itself)
- What leads to the Candida albicans infections in patients with APECED?
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